新生儿咽部巨细胞病毒感染状况的研究

Cytomegalovirus Infection in Pharyngeal Secretion of Neonates

目的：追踪观察新生儿咽部巨细胞病毒（ＣＭＶ）感染状况，进一步分析感染对其生长发育的影响。方法：采用聚合酶链反应（ＰＣＲ）和病毒分离方法检测４２例新生儿咽部分泌物中ＣＭＶ感染状况。结果：新生儿咽部ＣＭＶ感染率为１６．７％（７／４２），７例咽部ＣＭＶ阳性者母亲宫颈分泌物或外周血ＣＭＶＤＮＡ均阳性。宫颈或外周血ＣＭＶＤＮＡ阳性者其新生儿咽部感染的危险性为４３．７％（７／１６），自然分娩和剖宫产者新生儿咽部ＣＭＶ感染率分别为１２．５％（２／１６）和１９．２％（２／１６），二者无显著差异。结论：孕妇ＣＭＶ感染可通过宫内和产道传播给胎儿，剖宫产不能防止新生儿咽部感染。

Objective:We followed up the cytomegalovirus(CMV) infection in pharyngeal secretion of neonates for analysing the impact of infection on the development and growth of the neonates. Methods:PCR and virus isolation were used for detecting CMV infection in pharyngeal secretion of 42 neonates. Results: The incidence of CMV infection in pharyngeal secretion of neonates was 16.7% (7/42). All 7 pharyngeal positive neonates were born from cervical or peripheral blood positive mothers. The risk of pharyngeal CMV infection in neonates from those mothers with positive findings was 43.7% (7/16). Rate of CMV infection in pharyngeal secretion of neonates by normal delivery or cesarean section was 12.5%(2/16) and 19.2(5/26) respecively. We found no significant difference between them.Conclusions: CMV infection can be transmitted from pregnant women to their fetus. Pharyngeal infection in neonates can not be prevented by cesarean section.