红细胞铜锌超氧化物歧化酶与血清维生素C在糖尿病肾病时的变化

The Change of Copper, Zinc Superoxide Dismutase in Erythrocyte and Vitamin C in Serum with Diabetic Nephropathy

目的：探讨氧化与抗氧化在糖尿病肾病发生发展中的作用。方法：测定对照（Ｃ）组１５人及糖尿病蛋白尿正常（ＤＭⅠ）组、微量白蛋白尿（ＤＭⅡ）组、临床蛋白尿（ＤＭⅢ）组患者共５６例的红细胞铜，锌超氧化物歧化酶（ＳＯＤ）及血清维生素（ＶｉｔＣ）。结果：ＳＯＤ与尿白蛋白排泄率（ＵＡＥＲ）呈明显负相关，ＤＭⅡ组明显高于Ｃ、ＤＭⅠ组，低于ＤＭⅢ组（Ｐ＜０．０１）；ＶｉｔＣ与ＵＡＥＲ呈明显负相关（Ｐ＜０．０１），但ＤＭⅠ与Ⅱ组，ＤＭⅡ、Ⅲ组间Ｐ＞０．０５；ＳＯＤ、ＶｉｔＣ与ＨｂＡ１Ｃ间呈负相关，前者Ｐ＜０．０１，后者Ｐ＞０．０５。结论：抗氧化能力下降可能是糖尿病发生肾脏损伤的原因之一，并可反映损伤程度。

Objective:To study the role of oxygenation and antioxygenation in the genesis and development of diabetic nephropathy. Methods:We examined the copper and zinc SOD of RBC and serum vitamin C in control group (C group) and 56 patients who were divided into DMⅠ group (no proteinuria), DMⅡ group (microproteinuria) and DMⅢ group (clinical proteinuria). Results:① SOD has marked negative correlation with UAER (urinary albumin excretion rate). DMⅡ group is significantly higher than C group and DMⅠ group, lower than DMⅢ group (P<0.01).② Vitamin C has marked negative correlation with UAER (P<0.01),but P>0.05 between DMⅠ andⅡ group, DMⅡ andⅢ group. ③ SOD has negative correlation with HbA 1C (P<0.01).Vit C has negative correlation with HbA 1C (P>0.05).Conclusions:The decline of antioxygenation may be one of the reason leading to the renal injury in DM. It also can reflect the extent of injury.