不同促渗剂对黄芩苷离体鼠皮透过行为的影响

The effects of different penetration enhancers on transdermal behavior of Baicalin in rat in vitro

[目的]研究辛酸/癸酸甘油酯(Lab)、二乙二醇单乙基醚(TransP)以及丙二醇(PG)对黄芩苷透皮行为的影响。[方法]采用改良Franz扩散池,考察Lab、TransP和PG在不同浓度下,对黄芩苷离体鼠皮透过行为的影响。[结果]与空白组相比,3%TransP与5%PG的表观渗透系数增加了3.15和3.05倍,有差异(P<0.05),几种促渗剂对黄芩苷透过的增渗作用依次为3%TransP>5%PG>7%PG>5%TransP>7%TransP>3%PG>1%TransP>10%PG>5%Lab。[结论]3%TransP与5%PG的促渗效果比较明显,可进一步应用于黄芩苷透皮制剂中。

[Objective] To study the effects of Lab, Trans P and PG on the transdermal behavior of Baicalin in rat. [Methods] The Franz modified diffusion chamber was applied for evaluating the effect of different concentrations of each penetration enhancer （PE） on the permeability of Baicalin in vitro. [Results] Compared with control （P〈0.05）, 3% Trans P and 5% PG could increase the apparent permeability as much as 3.15 and 3.05 folds. The penetration rate with the PE： 3%Trans P〉5%PG〉7%PG〉5%TransP〉7%TransP〉3%PG〉1% TransP〉10%PG〉5%Lab. [Conclusion] The enhance effect of 3%TransP and 5%PG is significant, and is likely to apply in the further research.