肺部感染性疾病巨细胞病毒感染状态分析

The Statu of Cytomegalovirus Infcetion in Pulmonary Infective Disease

目的分析肺部巨细胞病毒（ＣＭＶ）感染状况及其意义。方法应用ＰＣＲ技术检测４５例肺部感染性疾病患者肺泡灌洗液（ＢＡＬＦ）、保护性标本刷（ＰＳＢ）洗涤液及血白细胞ＣＭＶＤＮＡ；应用ＥＬＩＳＡ技术检测血清ＣＭＶＩｇＭ。结果ＢＡＬＦ、ＰＳＢ、血白细胞ＣＭＶ－ＤＮＡ及血清ＩｇＭ的阳性率分别为３１．１１％，３５．５５％，１３．３３％和５１．１１％。肺部ＣＭＶ感染病毒血症的发生率为２８．５７％。肺癌与非肺癌ＣＭＶ感染率总体上差异无显著性（Ｐ＞０．０５），但小细胞肺癌并ＣＭＶ感染者病毒血症发生率高于非肺癌者（Ｐ＜０．０５）。结论（１）肺部感染性疾病合并巨细胞病毒感染状态常见，但仅少数发生病毒血症。

Objective\ To examine the relationship between cytomegalovirus(CMV) infection and pulmonary infection disease.\ Methods\ CMV DNA of the eluate of protected brushing,bronchial alveolus lavage fluid and WBC of venous blood were measured by means of PCR.\ Serum anti CMV IgM was measured by means of ELISA.\ Results\ The detectable rate of CMV from protected brushing eluate,bronchial alveolus lavage fluid,white blood cell,blood serum were 35.55%,31.11%,35.55%,13.33%,51.11%;28.57% of pulmonary CMV infection developed into virusemia.\ There was no significant difference in CMV infection rate between lung cancer complicated with pulmonary infection and non lung cancer(P> 0.05). \ In further analyses,the CMV infection rate of small lung cancer was higher than that of non lung cancer.\ Conclusion\ (1)It is quite common that pulmonary infection disease is complicated with the status of CMV infection,and only a few of which develop into virusemia.(2)Patients with small lung cancer have the higher rate of virusemia.