摘要
目的:探讨原发性肺癌LN和FN的表达与转移及预后的关系。方法:采用免疫组化LSAB法检测179例肺癌标本中LN和FN的表达。结果:中、高分化的肺鳞癌的LN的表达强度明显不同于低分化者(t*=3.07,2.67,P均<0.01),LN的表达强度在有无淋巴结转移的两组鳞癌间,差异具有显著性意义(χ2=11.13,P<0.05),LN和FN的表达强度在鳞癌5年以上生存组明显不同于半年内死亡组(t△=2.85,2.49,P△<0.01,<0.05),FN表达强度在3组不同生存期的肺腺癌间,差异具有显著性意义(Hc=7.53,P<0.05)。结论:LN和FN的表达可作为评估肺癌淋巴结转移及预后的有价值的指标。
Objective:To study the relationship between the expression of LN,FN and metastasis and prognosis of lung cancer. Methods: The expression of LN and FN were determined in 179 cases of lung cancer with LSAB method. Results:The expression of LN in moderate and well differentiated squamous cell lung cancer were significantly different from that of the low differentiated cases ( P <0.01). Significant difference of expression was also found between cases with and without lymph node metastasis ( P <0.05). The expression of LN and FN in the patients survived for more than 5 years markedly differed from those died within half a year ( P <0.05). The FN expression was also significantly different among the three groups of lung adenocarcinoma of variable survival times ( P <0.05). Conclusion: LN and FN expression can be used as a helpful marker for evaluating metastasis and prognosis of lung cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第10期734-737,共4页
Chinese Journal of Clinical Oncology
基金
山东省科研基金