坦度螺酮联合舍曲林治疗卒中后抑郁的临床研究

脑卒中后抑郁(Post stroke depression,PSD)是脑血管疾病常见的并发症之一,脑卒中后约60%的患者可发生抑郁[1-3],PSD是目前阻碍卒中病人神经功能及日常生活能力恢复的重要因素,可以使患者死亡率增加[4]。我们将符合脑卒中后抑郁的诊断标准的住院病人,随机分成两组,分别用坦度螺酮联合舍曲林和单用舍曲林治疗4周,来探讨坦度螺酮与舍曲林联合治疗脑卒中后抑郁的疗效。

Post stroke depression （PSD） is one of most frequent complication of cerebrovascular disease, almost 60% patients with the Post Stroke may have depression . PSD is now becoming an important factor in preventing Post Stroke patients＇ nerves function and their daily viability from recovery. It also can increase the death rate of patients . We divided the patient corresponded with the diagnostic criteria of PSD into two sets. One was treated with combination of Tandospirone and Sertraline, and the others were treated with Sertraline alone. The curative effect of the treatment with Tandospirone and Sertraline was investigated 4 weeks later.