新型卟啉光敏剂:同分异构体空间结构与光敏活性

Novel Porphyrin Photosensitizers:Spatial Structure and Photosensitivity of Two Kinds of Isomer

以2-硝基四苯基卟啉及其Cu(Ⅱ)、Ni(Ⅱ)配合物为原料,分别与1-萘酚、2-萘酚反应,合成了4对β-萘酚基四苯基卟啉同分异构体,并通过1HNMR、UV、IR、MS对新化合物进行了结构表征。比较了两类卟啉同分异构体作为光动力治疗光敏剂在光敏抗菌及光敏切割DNA方面的活性差异,并利用Chem3D软件的MM2分子力场计算方法确定了卟啉同分异构体的空间优势结构。结果表明,β-萘酚基四苯基卟啉同分异构体空间结构的非平面程度相当,光敏活性差异也不明显,卟啉的非平面性与光敏活性具有一定的一致性。

Four pairs of porphyrin isomer have been synthesized by using 2-nitrotetraphenylporphyrin and its Cu（Ⅱ）,Ni（Ⅱ）complex as reagents reacting with 1-naphthol and 2-naphthol respectively.The compounds have been characterized via 1HNMR,UV,IR,MS.The photosensitivities of these porphyrin isomers have been compared by antibacterial and DNA test.By calculation of MM2 molecular force field of Chem3D,the energy-minimized structures of porphyrin isomers have been obtained.The results suggest that the planarity of porphyrin isomer is consistent with its photosensitivity.