体外循环时凝血噁烷A_2的变化

Change of Plasma Thromboxane A 2 During the Cardiopulmonary Bypass

的：研究体外循环（ＣＰＢ）时凝血烷Ａ２（血栓素Ａ２，ＴＸＡ２）的变化。方法：２０例非紫绀型先天性心脏病患者，在ＣＰＢ开始５分钟，主动脉开放即刻，主动脉开放后５分钟、１０分钟、２０分钟及停ＣＰＢ时分别行动脉血和静脉血白细胞计数及ＴＸＡ２含量测定。结果：①主动脉开放后５分钟、１０分钟，动脉血白细胞计数显著低于静脉血（Ｐ＜０．０５），主动脉开放前、主动脉开放后２０分钟、停ＣＰＢ时，两者无显著差异。②ＴＸＡ２于主动脉开放后开始升高，１０分钟达峰值，后逐渐下降，但停ＣＰＢ时仍高于术前（Ｐ＜０．０５）；动脉血ＴＸＡ２含量于主动脉开放后５分钟、１０分钟均显著高于静脉血（Ｐ＜０．０５）。结论：①肺脏是ＣＰＢ期间ＴＸＡ２的主要来源之一，可能与肺脏大量白细胞隔离有关。

Objective:To investigate the change of plasma thromboxane A 2(TXA 2) during cardiopulmonary bypass. Methods:Thromboxane A 2 and leukocyte were determined in 20 patients with congenital heart disease.The blood samples were collected following cardiopulmonary bypass(CPB),aorta and at the end of CPB. Results:①The arterial leukocyte was significantly lower than the venous when 5 min,10 min after aorta opening( p <0.05).②The arterial TXA 2 concentration was significantly higher than the venous when 5 min,10 min after aorta opening.The arterial TXA 2 value peaked at 10 min after aorta opening.It was still higher than preoperation at the end of CPB( p <0.05). Conclusion:①The lung was one of the major sources of TXA 2.②The leukocyte sequestered in the lung during CPB.