阿立哌唑与奥氮平治疗精神分裂症的对照研究

Comparative study between aripiprazole and olanzapine in the treatment of schizophrenia.

目的比较阿立哌唑与奥氮平对精神分裂症患者的疗效及生活质量的影响。方法对68例精神分裂症患者,随机使用阿立哌唑与奥氮平治疗,疗程8周。采用阳性与阴性症状量表(PANSS)评定疗效,采用治疗中出现的症状量表(TESS)评定不良反应,以生活质量综合评定问卷(GQOLI-74)评定生活质量。结果两组均有显著疗效,阿立哌唑与奥氮平均可显著提高生活质量。两组间比较无显著差异(P>0.05)。阿立哌唑组主要不良反应为失眠、头痛;奥氮平组主要不良反应为体重增加、血糖升高。结论阿立哌唑与奥氮平对精神分裂症疗效相当,不良反应较少,均可提高患者生活质量。

Objective To investigate the efficacy and quality of life in schizophrenic patients treated by anplprazole and olanzapine . Methods A total of 68 patients with schizophrenia were randomly divided into aripiprazole group and olanzapine group for g - week treatment. Positive and Negative Symptoms Scale （PANSS） was used to evaluate the clinical efficacy ,Treatment Emergent Symptom Scale （TESS） for side effects and General Quality of Life Inventory （GQOLI - 74） for quality of life. Results The patients in both groups had significant clinical efficacy, and the two drugs obviously improved the quality of life . There were no significant differences in the efficacy and quality of life （ P 〉 0.05 ） between the two groups. The side effects of aripiprazole were insomnia and headache, and those of olanzapine were weight gain and increased blood glucose. Conclusion Aripiprazole and olanzapine are similar in the treatment of schizophrenia with fewer side effects, and they both improve quality of life.