西酞普兰合并小剂量奥氮平治疗脑卒中后抑郁的对照研究

Comparative study of citalopram plus low-dose olanzapine in the treatment of patients with poststroke depression.

目的观察西酞普兰合并小剂量奥氮平治疗脑卒中后抑郁的临床疗效和不良反应。方法70例脑卒中后抑郁患者随机分成西酞普兰组和西酞普兰合并小剂量奥氮平组,疗程8周。于治疗前,治疗后第1、2、4、6、8周末采用汉密尔顿抑郁量表(HAMD)评定疗效,并观察两组药物的不良反应。结果治疗第8周末,西酞普兰合并小剂量奥氮平组与西酞普兰组显效率分别为85.7%、65.71%,差异有统计学意义(P<0.05);西酞普兰合并小剂量奥氮平组在第1周末起效,西酞普兰组在治疗后第2周末起效;两组治疗后第1、2、4周末HAMD评分比较差异均有统计学意义(P<0.05),不良反应均较轻。结论西酞普兰合并小剂量奥氮平治疗脑卒中后抑郁起效快,疗效好,并能迅连改善睡眠障碍,不良反应轻。

Objective To explore the clinical effect and side effects of citalopram plus low - dose olanzapine in trea- ting patients with poststroke depression. Methods Seventy patients with poststroke depression were randomly divided in- to control group （citolopram） and combined group（ citalopram plus low - dose olanzapine）. The course of treatment was 8 weeks. The efficacy was assessed by Hamilton Depression Rating Scale（HAMD） before theatment went and at the end of lst,2nd,4th,6th and 8th after treatment. The side effects were observed. Results After 8 weeks,the improved rates were 85.7 % in combined group and 65.71% in control group, there was significant difference between two groups（P 〈 0.05）. Combined group took into effect at the end of 1 st week while control group at the 2nd weekend. The scores of HAMD showed significant differences at the end of lst,2nd and 4th weeks after treatment between two groups（P 〈0. 05）. The side effects in two groups were few. Conclusion Citalopram plus low - dose olanzapine has better effect and take into effect early, and improves sleeping quickly for treating patients with postroke depression.