摘要
许多疾病的发生与线粒体功能缺陷有关,有人统称为线粒体疾病[1]。为进行线粒体功能缺陷发生机制的分子遗传学研究,需要建立一个特殊的能将一个细胞的线粒体移向另一个细胞,或者引入新的基因进入线粒体的细胞模型,这就是无线粒体DNA(mitochodrialD...
出处
《北京医科大学学报》
CSCD
1998年第5期463-463,472,共2页
Journal of Peking University(Health Sciences)
基金
高等学校博士学科点专项科研基金
同被引文献6
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1Sherrate EJ, Thomas AW, Alcolado JC. Mitochondrial DNA defects: a widening clinical spectrum of disorders. Clinical Science, 1997, 92:225
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2Chomyn A. Platelet-mediate transformation of human mitochondrial DNA-less cells. Methods Enzymol, 1996, 264:334
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3King MP,Attardi G. Human cells lacking mtDNA:repopulation with exogenous mitochondria by complementation. Science, 1988, 246:500
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4Attardi G, Yonda M, Chomyn A. Complementation and segregation behavior of disease-causing mitochondrial DNA mutation in cellular model systems.Biochim Biophys Acta, 1995, 1271:241
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5Chomyn A, Lai ST, Shakeley R, et al. Platelet-mediated transformation of mtDNA-less human cells: analysis of phenotypic variability among clones from normal individuals and complementation behavior of tRNALys mutation causing myoclonic epilepsy and ragged red fibers. Am J Hum Geenet, 1994, 54:54
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6DiMauro S, Bonilla E, Davidson M, et al. Mitochondria in neuromuscular disorders.Biochim Biophys Acta,1998, 1366:199
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1高枫,李晓东,陈清棠.无线粒体DNA的人食管癌细胞系的建立[J].基础医学与临床,1999,19(5):92-95.
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2刘宗文,张中冕,杨家梅,田薇薇.人食管鳞癌EC9706细胞线粒体DNA与凋亡的关系[J].肿瘤防治研究,2010,37(8):878-881. 被引量:4
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3吴晓邡,闫秋,戴小珍,孟秋丽,姜鹤群.常见结直肠癌无线粒体DNA细胞株的建立[J].现代生物医学进展,2015,15(20):3805-3808. 被引量:1
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4张国桥,凌贤龙,陈正堂.细胞色素氧化酶Ⅱ在无线粒体DNA肝癌细胞系及亲本细胞系中表达的实验研究[J].现代医药卫生,2006,22(24):3709-3711. 被引量:2