腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症60例

S-adenosylmethionine Treatment of Intrahepatic Cholestasis of Pregnancy Clinical Observation of 60 Cases

目的观察S-腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症(ICP)的疗效。方法将120例ICP住院患者随机分为常规治疗组及腺苷蛋氨酸治疗组,常规组采用常规治疗,治疗组加用腺苷蛋氨酸治疗。治疗3周后观察并比较肝功能指标、瘙痒症状的改善情况,分娩后比较妊娠结局情况。结果治疗后治疗组肝功能指标改善及瘙痒评分变化与对照组比较均有极显著性差异,P<0.01。妊娠结局比较,胎儿宫内窘迫、新生儿窒息、羊水粪染例数两组比较无显著性差异,P>0.05;而早产、产后出血例数两组比较则有显著性差异,分别为P<0.05(早产)、P<0.01(产后出血)。结论S-腺苷蛋氨酸能有效治疗ICP,值得临床进一步推广。

Objective To observe the S - adenosy - L - methionine treatment of intrahepatic cholestasis of pregnancy （ICP） resuits. Methods 120 cases of ICP patients were randomly divided into conventional treatment group and S-adenosylmethionine treatment group, the treatment group with conventional treatment, observation group therapy with S- adenosylmethionine. 3 weeks after treatment to observe and compare the liver function indicators, itching symptoms to improve the situation, the outcome of pregnancy after childbirth compared the situation. Results After treatment, the observation group to improve liver function and pruritus score changes compared with the control group had a very significant difference, P 〈 0. 01. Comparison of pregnancy outcome, fetal distress, neonatal asphyxia, meconium - stained amniotic fluid group compared the number of cases no significant difference, P 〉0.05 ; and premature labor, postpartum hemorrhage compared two groups of patients there were a few significant differences, namely P 〈 0. 05 （premature）, P 〈 0. 01 （ post - partum haemorrhage）. Conclusion S- adenosyl - L - methionine can be effective treatment for ICP, is worthy of further promotion.