煤工尘肺患者血清白细胞介素-9和可溶性细胞间黏附分子-1水平变化及意义

Study on serum levels of IL-9 and sICAM1 in coal workers with pneumoconiosis

目的探讨煤工尘肺患者(CWP)血清白细胞介素-9(IL-9)和可溶性细胞间黏附分子-1(sICAM-1)水平变化及意义。方法用双抗体夹心酶联免疫吸附法检测106名CWP患者(CWP组)、55名具有与CWP组相同接尘条件的0+煤矿工人(0+组)、62名具有相同接尘史但未患CWP的煤矿工人(接尘对照组)及47名非接尘井上健康工人(正常对照组)血清IL-9和sICAM-1水平。结果与正常对照组比较,接尘对照组和0+组IL-9水平明显升高,差异均具有统计学意义(P均<0.05),而CWP组则轻度升高(P>0.05);接尘对照、0+及CWP三组sICAM-1水平均明显降低,差异均具有统计学意义(P<0.05和P<0.01)。CWP组IL-9水平明显低于接尘对照组和0+组,差异均具有统计学意义(P均<0.05),接尘对照组和0+组比较无明显变化(P>0.05)。sICAM-1水平在接尘对照、0+和CWP三组中均无明显改变(P均>0.05)。IL-9和sICAM-1水平在Ⅰ期CWP和Ⅱ期+Ⅲ期CWP以及不同接尘时间中均无显著变化(P均>0.05)。CWP组IL-9和sICAM-1无明显相关性(r=0.024,P>0.05)。结论血清IL-9和sI-CAM-1水平可能与CWP有关,对CWP进程具有一定提示作用;IL-9水平有助于鉴别CWP患者和0+煤矿工人,对CWP的诊断可能具有一定的参考价值。

Objective To explore the changes and significance of IL-9 and sICAM-1 levels in serum of coal workers with pneumoconiosis（CWP）.Methods Serum levels of IL-9 and sICAM-1 were determined by ELISA method in 106 CWP patients（as CWP group）,55 0＋ coal workers（0^＋ group）,62 healthy coal workers（dust control group）and 47 healthy workers on the ground（control group）.Results Compared with control group the serum IL-9 level in 0^＋ or dust control group were significantly higher（P〈0.05）,however,the serum levels of sICAM-1 in dust control, 0^＋ and CWP group were significantly lower （P 〈0. 05 -0. 01 ）. While the serum level of IL-9 in CWP group was significantly lower than those in dust control and 0^＋ group, respectively. Conclusions The serum levels of IL-9 and slCAM-1 may be related to the progress of CWP, the serum level detection of IL-9 may be useful in differential diagnosis of CWP from 0^＋ coal workers.