锌对抗氧化功能及脂类代谢的影响

Effects of zinc glucose on antioxidation and lipids metabolism

为探讨锌对抗氧化功能及脂类代谢的影响，选择健康志愿者３６例，男女各１８例，口服葡萄糖酸锌（０．２／ｄ），连续８周，动态观察ＲＢＣＳＯＤ、ＲＢＣＧＳＨ－Ｐｘ、ＬＰＯ及ＴＣ、ＴＧ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ、ａｐｏＡＩ及ａｐｏＢ１００变化。结果显示服锌２周后ＲＢＣＳＯＤ活性下降，随锌摄入量增加，持续降低，ＬＰＯ同时升高达最高值，随着ＲＢＣＳＯＤ活性下降，ＲＢＣＧＳＨ－Ｐｘ活性升高，ＬＰＯ下降，但停药４周后仍高于服药前１倍，ＧＳＨ－Ｐｘ未能完全代偿机体抗氧化功能。随锌的摄入，ＴＣ于第二周升高，之后呈递增性改变，ＴＧ、ＬＤＬ－Ｃ及ａｐｏＢ１００升高，ＨＤＬ－Ｃ于第２周降低，之后呈递减性改变。ａｐｏＡＩ也降低。健康人摄入锌能抑制抗氧化功能，干扰脂类代谢。

In order to explore effect of zinc glucose administration on antioxidation function and lipids metabolism,36 healthy volunteers were selected and administrated 200mg of zinc glucose per day for eight weeks.RBC SOD,RBC GSH Px、LPO,TC、TG、HDL C、LDL C、apo AI and apo B 100 were determined for five times.After subjects received zinc,RBC SOD activities decreased.As the intake of zinc increased,RBC SOD activities decreased constantly.At the same time,RBC GSH Px activities rose but level of LPO first rose and then lowered.The level of LPO was still over one time higher than before although RBC GSH Px activities rose.Change of lipids metabolism was very significant.After receiving zinc,TC,TG,LDL C and apo B 100 increased,but HDL C and apo AI decreased.Zinc administration might inhibit antioxidation function of human body and affect lipids metabolism,therefore zinc administration might result in arteriosclerosis.