中药当归对大鼠坐骨神经损伤后髓鞘再生的形态研究

A Morphometric Study on the Effects of the Chinese Drug Danggui on the Sheath Regeneration after the Sciatic Nerve Injiury

为探讨中药当归对周围神经损伤后的再生作用，对大鼠坐骨神经造成ＳｅｄｄｏｎⅡ类损伤，分别进行２个时间点（１０ｄ，２０ｄ）的当归治疗。采用图像分析法测定有髓神经纤维髓鞘的周长、最大径、最小径和面积４项参数，并进行透射电镜观察。结果显示２个当归治疗组髓鞘恢复均较各自损伤对照组好。

In order to investigate the effects of the Chinese drug danggui (angelica sinensis) on the regeneration of the injured peripheral nerve, we used a model with the second degree of seddon injury classification for rat’s sciatic nerve. We perfomed the danggui therapy at 2 time points(10,20 days) respectively. Using the image analysis method, we measured the 4 parameters(perimeter, maximum diameter, minimum diameter and square) involving the sheath of the myelinated fibers. We made a morphometric observation of the sheath by transmitting election microscopy. The results showd that the sheath recovery of the danggui therapy groups at both time points was better than that of their control group respectively, but it is not mornal yet.