草酸艾司西酞普兰的合成研究

Synthesis of Escitalopram Oxalate

目的合成抗抑郁药草酸艾司西酞普兰。方法以5-氰基苯酞为原料,经过两次格氏反应后水解,用(+)-DTTA拆分、成环后成盐而得到。结果所得产物结构经红外光谱、核磁共振氢谱及质谱确证。结论本方法合成工艺简单,合理可行。

OBJECTIVE To synthesize antidepressant drug of escitalopram oxalate.METHODS Escitalopram oxalate was synthesized from 5-cyanophthalide by twice grignard reaction,hydrolysis,the optical resolution with（＋）-DTTA,cyclization and then salification.RESULTS The structure of the product was determined by IR,MS and 1H NMR spectra.CONCLUSION This procedure was simple,reasonable and feasible.