降钙素原与社区获得性肺炎病情严重度评估

Role of procalcitonin in the evaluation of community - acquired pneumonia severity

目的探讨社区获得性肺炎（CAP）病情严重度与降钙素原（PCT）的相关性，为CAP病情严重度的评估提供实验室依据。方法收集2008-10—2009-02期间我院收治的单纯CAP病例共38例，在入院24h、7d分别测定PCT、C-反应蛋白（CRP）、白细胞计数（WBC），应用肺炎病情严重度评分（PSI）评估病情。结果试验组入院24hPCT较健康对照组升高，差异有统计学意义（P〈0.01）。入院24h及7d：PCT均与PSI相关（r=0.539，r=0.472；P〈0.05）；入院7dWBC与PSI相关（r=0.381，P〈0.05），CRP与PSI无相关性。结论与CRP、WBC相比，PCT能够更好反映CAP病情严重程度，可用于动态监测CAP病情。

Objective To discuss the correlation between procalcitonin（PCT）, C - reactive protein （CRP）, white blood cell count（WBC） and community-acquired pneumonia （CAP） severity. Methods Thirty - eight CAP patients without complications of COPD, bronchiectasia or other chronic lung diseases, and sixteen healthy controls were enrolled to the study. Serum PCT, CRP and WBC were measured and Pneumonia Severity Index （PSI） were calculated on the first day and the seventh day after their admission. Results The increase of PCT concentrations were obvious in CAP group （P〈0.01）. On the first day, the correlation coefficient between PCT and PSI was significantly correlated （ r = 0.539, P 〈0.01）, but there were no correlation between CRP and PSI（r=0.044,P 〉0.05）,between WBC and PSI（ r =-0.007 ,P 〉 0.05） respectively. On the seventh day, the correlation coefficient between CRP and PSI was non - correlated （r= 0.183,P 〉 0.05 ） , but between PCT and PSI （ r = 0.472 ,P 〈 0.05 ） , WBC and PSI（ r = 0.381 ,P 〈0.05） were correlated respectively. Conclusion Serum PCT levels in CAP group were markedly elevated than that in control group. As a marker of pneumonia severity, PCT was superior to CRP and WBC.