复方天麻蜜环糖肽片对慢性脑供血不足患者血浆一氧化氮和内皮素、脑血流动力学及认知功能的影响

Influence of compound Armillaria mellea tablets on plasma NO and ET,cerebral blood flow dynamics and cognitive function of patients with CCCI

目的:探讨复方天麻蜜环糖肽片对慢性脑供血不足(CCCI)患者血浆一氧化氮(NO)和内皮素(ET)含量、脑血流动力学及认知功能的影响。方法:已确诊的70名CCCI患者随机分为治疗组38例和对照组32例,对照组为常规治疗,治疗组在对照组基础上加服复方天麻蜜环糖肽片,1个月为一疗程;服药前后分别对2组患者血浆NO和ET进行检测,经颅多谱勒(TCD)检测大脑中动脉脑血流多谱勒信号,用简易智能状况量表(MMSE)进行认知功能评定。结果:2组CCCI患者的认知功能治疗前无差异。治疗后,治疗组认知功能评分、血流速度(Vm)和NO含量升高(P<0.05);大脑中动脉脉动指数(PI)、阻力指数(RI)及血浆ET含量下降(P<0.05)。结论:复方天麻蜜环糖肽片可改善CCCI患者的认知功能,其机制可能与调节患者血浆NO和ET含量、提高脑血管血流量有关。

OBJECTIVE To explore the influence of compound Armillaria Mellea tablets on plasma NO and ET, cerebral blood flow dynamics and cognitive function of patients with CCCI. METHODS The 70 patients with CCCI were randomly divided into treatment group （38 cases） and control group （32 cases）. The control group received conventional therapy; the treatment group received compound Armillaria Mellea tablets, besides conventional therapy. One month for each course of treatment. Plasma NO and ET were examined, the DOP Doppler signals of cerebral blood flow in artery were detected with TCD, the cognitive function were evaluated with mini-mental state examination （MMSE）. RESULTS The cognition function of two groups differs little before treatment. After treatment, cognitive function score, mean velocity and plasma NO of treatment group increased significantly （P〈0. 05）; PI, RI in cerebral central artery and plasma ET reduced significantly （P〈0. 05）.CONCLUSION Compound Armillaria Mellea tablets could improve the cognition function of patients with CCCI, its mechanism might relate to adjusting plasma NO and ET, increasing cerebral blood flow.