胆乐汤抗炎利胆作用的实验研究

Experimental Study on Anti-inflammatory and Choleretic Effect of DanLe Decoction

目的:研究胆乐汤的抗炎利胆作用.方法:用二甲苯致小鼠耳廓肿胀法观察胆乐汤的抗炎作用;以胆汁分泌量为指标,测量大鼠在给药后的胆汁流量变化。结果:胆乐汤的高中剂量组对二甲苯所致小鼠具有明显的消炎作用(P<0.01),低剂量组有一定的抗炎作用;胆乐汤高剂量组能显著增加大鼠胆汁分泌量(P<0.01),且高低中高剂量组随着给药剂量增加胆汁分泌量有增加的趋势,呈一定的量效关系。结论:胆乐汤具有一定的抗炎利胆作用。

Objective： To study the anti-inflammatory and choleretic effect of DanLe Decoction. Methods ： To observe anti-inflammatory effect of Danle decoction by Xylene-indueed mouse ear edema method ;The bile flow volume was determined to show the variation of biliation in mice and rat. Results ： The high dose group of para-xylene-induced mice showed significant anti-inflammatory effect （ P 〈 0. 01 ） ,low dose group have a certain anti-inflammatory effect; The bile flow volume of mice and rat increased obviously on high dose group（P 〈 0. 01 ） and it showed the dose-effect relationship that the more bile excreted while the more drugs were given. Conclusion： DanLe Decoction has anti-inflammatory and choleretic effect.