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乳酸杆菌对ApoE^(-/-)小鼠动脉粥样斑块形成抑制作用

Loctobacillus casei inhibits atherosclerotic plaque formation in apoE-deficient mice
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摘要 目的研究乳酸杆菌对载脂蛋白E(apoE)基因缺陷小鼠动脉粥样斑块形成的影响,探讨乳酸杆菌抗动脉粥样硬化作用机制。方法将apoE基因缺陷(ApoE-/-)小鼠随机分为4组:对照组(A组)、乳酸杆菌108组(B组)、乳酸杆菌1010组(C组)、乳酸杆菌1012(D组)。A组喂养正常小鼠饲料(AIN-93),B、C、D组在正常饲料基础上添加108,1010,1012cfu/mL乳酸杆菌喂养16周,检测动脉粥样斑块面积。结果乳酸杆菌1012,1010,108cfu/mL组的主动脉窦动脉粥样斑块面积分别为13.98%,17.36%,21.54%,比对照组的30.51%分别低54.18%,43.10%,29.40%,差异有统计学意义(P<0.05);随着乳酸杆菌浓度增加,主动脉窦动脉粥样斑块面积减少,但乳酸杆菌各组之间动脉粥样斑块面积差异无统计学意义。结论乳酸杆菌可以抑制ApoE-/-小鼠动脉粥样斑块形成,具有抗动脉粥样硬化作用。 Objective To explore the effect of Lctobacillus casei on atherosclerotic plaque formation in apoE-deficient mice and its mechanism in anti-atherogenelsis. Methods After 16 weeks intervention with LctobaciUus casei, atherosclerotic plaque area in aortic sinus was assessed with image analysis. Results The plaque area in aortic sinus in mice fed with Lcto- bacillus casei diet was less than that of positive group. Conclusion The result suggests that Lctobacillus casei has the capacity of inhibiting atherosclerotic plaque formation and progression in apoE-deficient mice.
作者 唐志红 夏敏 朱惠莲 侯孟君 马静 凌文华
机构地区 中山大学公共卫生学院
出处 《中国公共卫生》 CAS CSCD 北大核心 2009年第11期1352-1354,共3页 Chinese Journal of Public Health
关键词 apoE基因缺陷(ApoE-/-)小鼠 乳酸杆菌 动脉粥样斑块 apoE-deficient mice Lctobacillus casei atherosclerotic plaque
分类号 R743.1 [医药卫生—神经病学与精神病学]
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中国公共卫生
2009年 第11期

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