益气活血解毒汤对实验性动脉粥样硬化家兔CRP水平及主动脉斑块的影响

Effects of Yiqihuoxuejiedu Decoction on the CRP and Aorta Plaque in Experimental Atherosclerosis Rabbits

目的观察中药复方益气活血解毒汤对实验性动脉粥样硬化(AS)家兔C反应蛋白(CRP)及主动脉斑块的干预作用及其机制。方法24只日本雄性大耳白兔随机分为正常对照组、模型对照组、益气活血解毒汤组、辛伐他汀组。采用高脂饲料喂饲建立兔AS模型,其中益气活血解毒汤组及辛伐他汀组造模同时灌胃相应药液,而前两组以等量蒸馏水灌胃。10周后测定各组家兔斑块面积及血清CRP的含量。结果模型对照组CRP较正常对照组升高,益气活血解毒汤组及辛伐他汀组CRP明显低于模型组,与正常对照组相近。模型对照组斑块面积较空白对照组明显升高,益气活血解毒汤组及辛伐他汀组斑块面积均低于模型对照组,益气活血解毒汤组斑块面积与辛伐他汀组比较有所降低。结论益气活血解毒汤对AS有明显的预防和治疗作用,其可减少斑块的面积,降低血清CRP含量,从而起到稳定AS斑块的作用。

Objective： To observe the influence and the mechanism of Yiqihuoxuejiedu Decoction on levels of serum C reactive protein （CRP） and aorta plaque in rabbits with atherosclerosis. Methods： 24 Japanese male rabbits were randomly divided into four groups： the control group, the model group, the Yiqihuoxuejiedu Decoction group and the simvastatin group. The model of AS was established by feeding the cholesterol contained fodder. The Yiqihuox- uejiedu Decoction group and the simvastatin group were given corresponding drugs by intragastric administration during model establishment. The other two groups were given equivalent amount normal saline by intragastric ad- ministration. After ten weeks, the levels of CRP and the area of aorta plaque were measured. Results： The level of CRP of model group higher that of control group. Levels of CRP of the Yiqihuoxuejiedu Decoction group and the simvastatin group were lower than that of the model group obviously. But their CRP levels and were similar to control group. Compared with the control group, the area of plaque in model group was significantly increased. Areas in Yiqihuoxuejiedu Decoction group and simvastatin group were lower than those in model group. Conclusion： Yiqihuoxuejiedu Decoction is obviously in treating and preventing the atherosclerosis. It could decrease the area of plaque and the level of CRP, thereby it could stable atherosclerotic plaque.