含异噁唑环的药物先导化合物的设计、合成与活性研究

Development of the Studies on the Design, Synthesis and Bio-Activity of Isoxazole-contained Derivatives

本文综述了将取代异噁唑作为药效活性基团,引入到四类不同母体分子中,所合成的新型化合物分别具有抗菌、消炎等生物活性,成为有价值的药物先导化合物的研究进展。

Isoxazole derivatives have been used as key intermediates in synthesis and have been investigated intensively for the last several years because of their biological activities. In this review, isoxazole ring was introduced into the four types of different molecules as substituent, the designed compounds were synthesized with multi-steps and the structures of the formed new compounds were confirmed by NMR, MS and IR etc. Preliminary bio-tests showed that some of the compounds exhibited interesting properties as anti-biotics and anti-inflammatory agents.