血管活性物质与心血管疾病患者的相关性分析

Blood vessel active material and cardiovascular disease patient's relevant analysis

目的检测冠心病(CHD)和原发性高血压(CH)患者血中NO、CNP、AngⅡ、CGRP和ET的含量,探讨其相关性。方法选择EH患者62例,CHD患者54例为实验组,正常健康者45例为对照组,采用放射免疫法检测血中CNP、AngⅡ、CGRP、ET含量,硝酸还原酶法测定NO含量。结果EH和CHD组分别与对照组比较,CNP、AngⅡ、ET含量明显增高(P<0.01,0.05),NO、CGRP则明显降低(P<0.01,0.01);两组患者CNP、AngⅡ与CGRP之间具有显著负相关性(EH组r=0.556,P<0.01;CHD组r=0.419,P<0.05)。结论检测EH和CHD血中CNP、NO、AngⅡ、CGRP、ET含量变化,对心血管疾病的发病机理研究及其防治具有重要意义。

Objective Examination coronary disease （CHD） and primary hypertension （CH） in patient blood NO, CNP, Ang Ⅱ , CGRP and the ET content, discusses its relevance. Methods Chooses the EH patient 62 examples, the CHD patient 54 examples is an experimental group, the normal healthy persons 45 examples are the control groups, uses the emission immunization to examine in the blood CNP, Ang Ⅱ , CGRP, the ET content, the nitric acid rcductases law determines the NO content. Results EH and the CHD group compares separately with the control group, CNP, AngⅡ , The ET content obvious markup（P 〈0. 01,0. 05） , NO, CGRP obviously reduce（ P 〈 0.01,0. 01 ） ; Two group of patient CNP, Ang Ⅱ Has the remarkable inverse correlation with CGRP between（ EH group r = 0. 556, P 〈 0. 01 ;CHD group r = 0. 419, P 〈 0. 05 ）. Conclusion Examines EH and in the CHD blood CNP, NO, Ang Ⅱ , CGRP, the ET content change, has the important meaning to the cardiovascular disease＇ s pathogenesis research and the prevention.