相转移催化法合成7-羟基黄酮的研究

Study on synthesis of 7-hydroxyflavone with phase-transfer catalysis

以2,4-二羟基苯乙酮与苯甲酰氯在相转移催化剂四丁基硫酸氢铵催化下,一锅法反应,得到7-羟基黄酮(Ⅲ),产品收率60%,对Ⅲ的反应机理进行了推测,对于Ⅲ质谱表征结果进行了分析。以间苯二酚(Ⅰ)与冰醋酸反应,制得原料2,4-二羟基苯乙酮(Ⅱ),产品收率达到70%。

7-Hydroxyflavone （Ⅲ） was obtained by means of phase-transfer catalysis from 2, 4-di- hydroxyacetophenone and benzoyl chloride using tetrabutylammonium bisulfate as phase transfer catalyst through one-pot reaction. The yield of Ⅲ was 60%. Mechanism for Ⅲ formation was proposed, and mass spectrum of m was resolved. 2,4-Dihydroxyacetophenone （ Ⅱ ） was also synthesized from resorcinol （ I ） and acetic acid, the yield of I1 was 70%.