对甲氧基苯基丙酮的合成

The synthesis of p-methoxyphenylacetone

报道了对甲氧基苯基丙酮的合成方法。由对甲氧基苯甲醛和2-氯丙酸甲酯为原料,经环合、水解和亚硫酸氢钠处理,再进行减压蒸馏获得目标产物。合成总收率80%以上,产品纯度达98%以上。

A synthetic method for p-methoxyphenylacetone from p-methoxybenzaldehyde and methyl 2-chloropropionate was described. Target compound was prepared through cyclicondensation,hydrolysis, treatment with sodium bissulfite and distillation at reduced pressure,with the yield over 80% and purity over 98%.