多器官功能障碍综合征患者急性呼吸窘迫综合征流行病学调查

Epidemiology of acute respiratory distress syndrome in the patients with multiple organ dysfunction syndrome in China:Analyse of the 1087 MODS patients with the multi-centered,prospective method

目的调查国内多器官功能障碍综合征(MODS)患者急性呼吸窘迫综合征(ARDS)的流行病学情况。方法采用多中心、前瞻性调查方法,分析2002年3月至2005年1月全国11省市、37家三级医院1087例MODS患者的病例情况。结果1087例患者中,ARDS的发生率、病死率分别为61.2%、63.6%。其中入住ICU患者其28天病死率为57.9%。MODS患者ARDS发生及死亡的高危因素分别为系统炎性反应综合征(SIRS)、MODS总评分,高龄、Glasgow言语反应总评分等等。与其发生与否相关的实验室检查有外周血白细胞总数及动脉血氧浓度测定。结论MODS患者中ARDS发生率较高,其发生及死亡高危因素有高龄、全身炎症反应综合征等。患有ARDS的MODS患者的ICU28天死亡率较无ARDS患者要高。

Objective To investigate the epidemiology of acute respiratory gastrointestinal dysfunction in the MODS patients in China. Methods Prospectively collected data of 1087 MODS patients between March 2002 and January 2005 were analysed. Patients were recruited from 37 tertiary hospitals of 11 provinces in China. Results The incidence and the mortality of ARDS in the MODS patients were 61.2% and 63.6% ,repectively. The mortality within 28 days of ICU hospitalization was 57. 9%. The risk factors of occurance and death included SIRS, total rating score of every organ, aging and Glasgow rating score and so on. The laborotary examinations associated with the occurance of ARDS included the amount of white blood cells of peripheral blood and the oxygen concentration of aterial blood. Conclusion MODS patients had high incidence rate of ARDS. And several risk factors influence the occurance of ARDS. MODS patients with ARDS had higher 28-day-hospitalization motality than patients without it.