磁共振成像诊断肌萎缩侧索硬化现状与研究进展

Progress of MRI study on amyotrophic lateral sclerosis

肌萎缩侧索硬化以上、下运动神经元和锥体束变性为特征,目前临床尚缺乏客观有效的上运动神经元损害的评价指标。常规MRI、磁共振波谱、弥散张量成像、脑功能成像和磁共振体素形态学定量分析已经应用于肌萎缩侧索硬化的临床诊断及相关研究。MRI无创、无辐射和易接受的优势使其在肌萎缩侧索硬化的诊断、病情监测和治疗等方面具有极大应用前景。

Summary： ALS is a progressive neurodegenerative disease affecting both lower and upper motor neurons, including the py- ramidal tract. There have been no objective and effective method to evaluate the lesions of upper motor neurons. With non- invasive, sensitive and macroscopic advantages, the application of Regular MR, MRS, DWI, function MR and VBM on ALS will undoubtedly have great potentials in the diagnosis, disease monitor and therapy of ALS.