隐匿性丙型肝炎病毒感染与慢性丙型肝炎的比较分析

Comparative analysis between occult hepatitis C virus infection and chronic hepatitis C

目的:比较隐匿性丙型肝炎病毒(HCV)感染者与慢性丙型肝炎(CHC)患者的特点。方法:选择51例隐匿性HCV感染者和52例未经治疗的CHC患者,两组患者的年龄、性别、肝功能异常的持续时间相匹配,分别比较两组患者的肝功能指标和外周血单个核细胞(PBMCs)中的丙型肝炎病毒核酸(HCV RNA)含量。结果:CHC患者的天门冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、甲胎蛋白(AFP)显著高于隐匿性HCV感染者(P<0.01),而胆固醇(Ch)和甘油三酯(TG)则显著低于后者(P<0.01),γ谷氨酰转肽酶(GGT)在两组感染者中差异无显著性意义(P>0.05);CHC患者的PBMCs中HCV RNA平均含量显著高于隐匿性HCV感染者(P<0.01)。结论:隐匿性HCV感染者病情严重程度不如CHC患者,这可能与其PBMCs中的病毒载量高低相关。

Objective： To compare the characteristics of patients with occult HCV infection against those of patients with chronic hepatitis C. Methods： It was compared to clinical features of 51 patients with occult HCV infection and 52 untreated chronic HCV patients （ anti-HCV and serum HCV RNA positive）, matched for age, sexuality, duration of abnormal liver function tests and HCV RNA concentration in their peripheral blood mononuclear cells （PBMCs） . Results： Aspartate aminotransferase （AST） and alanine aminotransferase （ALT） were higher （ P 〈 0. 01 ） in chronic HCV, but cholesterol （Ch） and triglycerides （TG） were significantly higher in patients with occult HCV infection （P 〈 0.01 ）, Chronic HCV patients had higher alpha-foetoprotein （AFP） levels （ P 〈 0. 01 ）, gamma-glutamyl transpepetidase （GGT） level, no significant difference was found in the percentage of with abnormal values of this enzyme in each group （ P 〉 0. 05 ） ; HCV RNA concentration of PBMCs was higher （P 〈0. 01 ） in patients with chronic HCV than in occult HCV infection. Conclusion： The occult HCV infection is a milder disease than chronic HCV, and this could be related to the significantly lower HCV RNA concentration of PBMCs in occult HCV.