抗HBs-抗独特型抗体对病人产生抗HBs的影响

The Influences of Anti-HBs-idiotype Antibody Upon the Ploduction of Anti-HBs in patients

乙型肝炎病毒感染时常有免疫失控,例如出现各种血清抑制因子等,但机制大多不明。由于独特型及抗独特型抗体在免疫调控网中起重要作用,作者对此采用 Irshad 法检测了70例 HBsAg(-)血清,156例 HBsAg(+)血清中抗 HBs 的抗独特型(抗 HBs-抗 Id),并加以分析报告如下:

By the method of Irshad we investigated the serum anti-HBs-idiotypeantibodies of 156 cases of hepatitis B It was found that the patients withchronic active hepatitis often have higher titers of anti-HBs-idiotype antibodiesthan those with acute hepatitis,chronic persistent hepatitis and HBsAg carriers.Besides,the anti-HBs-idiotype antibodies are more frequently associated withthe positivity of other viral replication markers such as HBV DNA-polymerase,HBeAg and pHSA-receptor.The relationship between anti-HBs-idiotype antibodyand replication markers is unclear.It was postulated that the anti-HBs-idiotypeantibody may play a role in the inhibition of anti-HBs formation and thereforemay enhance the viral replication.