ω,ω-二溴-对苯基苯乙酮的合成研究

Study on Synthesis of ω,ω-Dibromo-p-phenyl Acetophenone

以对苯基苯乙酮和溴素为原料、冰醋酸为反应介质,合成了ω,ω-二溴-对苯基苯乙酮。考察了原料配比、反应温度、反应时间等因素对反应收率的影响。优化合成条件:n(溴素)∶n(对苯基苯乙酮)=2.2∶1,反应温度45～50℃,反应时间2.5h。产品总收率89.7%,熔点114～116℃。产物结构经红外光谱、核磁波谱表征。

ω,ω-Dibromo：-p-phenyl acetophenone was synthesized from p-phenyl acetophenone and bromine in glacial acetic acid in 89.7% yield under optimized reaction conditions： n（bromiue） ： n（p-phenyl acetophenone） = 2.2 ： 1, reaction temperature 45-50℃, reaction time 2.5 h. The structure of the product was confirmed by FTIR, 1H NMR and 13C NMR.