缬沙坦与贝那普利联合治疗充血性心力衰竭的疗效

Valsartan and Benazepril in the Treatment of Congestive Heart Failure

目的:评价缬沙坦(valsartan)与贝那普利(benazepril)联合治疗充血性心力衰竭(CHF)的疗效。方法:100例CHF患者在应用洋地黄、利尿剂、β受体阻断剂治疗的基础上,随机分为A组(n=50);口服缬沙坦80mg/d,贝那普利(5～40)mg/d;B组(n=50);口服贝那普利(5～40)mg/d。治疗前、后分别进行心功能(NYHA分级)评估,心电图、超声心动图检查。结果:治疗12周后两组左房内径(LA)、左宣舒张末期容量(LVEDV)、左室收缩末期容量(LVESV)、左心室射血分数(EF)、短轴缩短率(FS)、心输出量(CO)、心排血指数(CI)均有显著改善(P均<0.05)。LVEDV、LVESV、EF、FS及心功能改善总有效率A组与B组比较改善更为显著(P<0.05)。结论:缬沙坦与贝那普利联合治疗CHF优于单用贝那普利。

Objective： To evaluate the effects and safety of benazepril jointed valsartan on patients with congestive heart failure （CHF）. Methods：100 patients ,who had unsatisfactory results under conventional digitals, diuretics ,β-blocking agent therapy ,are randomly divided into group A and group B., Group A（n=50） is given benazepril （5-40）mg/d and valsartan 80mg/d. Group B（n=50） is given benazcpril （5-40）mg/ d. The changes of NYHA class , electrocardiogram and echocardiography will be observed.Results：After eight weeks therapy ,LA atrium diameter, LVend-distolic volume（EDV）,LV end-systolic volume（ESV）, left ventricular ejection fraction （EF）, Fraction shortening（FS）,cardiac output （CO） , Cardiac index （CI） were improved significantly in both groups（p〈0.05） .LVEDV, LVESV EF,FS and NYHA class were more significant in group A than those in group B （P〈0.05）.Conclusion： Valsartan combined benazepril is more effective than benazepril in the treatment of the patients with CHF.