血管内皮生长因子及其受体在肿瘤治疗中的应用

The application of VEGF and VEGFR in treatment for tumor

通过血管内皮生长因子（VEGF）和血管内皮生长因子受体（VEGFR）来治疗肿瘤，可以由基因和细胞分子水平等多种途径获得，例如，可用单克隆抗体中和靶目标、或用小分子抑制剂抑制靶目标信号传导、或通过改变靶目标基因表达等。抗VEGF及其VEGFR可以单独应用，也可与抗其他生长因子、放疗等其他方法相结合，来增加抑制肿瘤生长的效果。

To treat tumor by vascular endothelial growth factor and its receptor may approach by gene and cell molecular level ,for instance, monoclonal antibody neutralize target objective, micromolecule inhibitor to inhibit target objective signal conduction,change target gene expression and so on. Resisting vascular endothelial growth factor and its receptor may be applied alone, also may combine with anti-other-growth factor or radiotherapy to increase the effect of inhibiting tumor growth.