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Effects of trimetazidine on atrial structural remodeling and platelet activation in dogs with atrial fibrillation 被引量:8

Effects of trimetazidine on atrial structural remodeling and platelet activation in dogs with atrial fibrillation
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摘要 Atrial fibrillation (AF) is one of the most common .arrhythmias in clinical practice. AF results in electrophysiological alterations which involve increased atrial effective refractory period and atrial effective refractory period dispersion, reduced rate adaptation of atrial effective refractory period, and slowed atrial conduction. These variances promote their own maintenance-AF begets AF.1 Previous study suggested that Ca^2+ overload and metabolic derangement contributed to electrophysiological remodeling in AF. However, we did not demonstrate a persistent disturbance in energy metabolism during AF in our previous study, Atrial fibrillation (AF) is one of the most common .arrhythmias in clinical practice. AF results in electrophysiological alterations which involve increased atrial effective refractory period and atrial effective refractory period dispersion, reduced rate adaptation of atrial effective refractory period, and slowed atrial conduction. These variances promote their own maintenance-AF begets AF.1 Previous study suggested that Ca^2+ overload and metabolic derangement contributed to electrophysiological remodeling in AF. However, we did not demonstrate a persistent disturbance in energy metabolism during AF in our previous study,
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2009年第18期2180-2183,共4页 中华医学杂志(英文版)
关键词 ATRIALFIBRILLATION structural remodeling THROMBOSIS TRIMETAZIDINE atrialfibrillation structural remodeling thrombosis trimetazidine
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  • 1韩薇,李为民,宋丽云,李悦,杨树森,黄永麟,甘润涛,寇俊杰,梗建强.实验性心房颤动血栓形成时内皮型一氧化氮合酶和纤溶酶原激活剂抑制物-1的变化[J].中华心血管病杂志,2005,33(1):69-72. 被引量:10
  • 2李为民,韩薇,李曦,谢宝栋,赵继义,王岚峰.心房颤动患者左心房血栓形成的可能机制研究[J].中华心律失常学杂志,2005,9(3):180-183. 被引量:6
  • 3刘智敏,东云华,寇瑛莉.心脏手术中心肌组织高能磷酸化合物的高效液相色谱测定及比较研究[J].色谱,1995,13(4):286-287. 被引量:1
  • 4Wijffels MC, Kirchhof CJ, Dorland R, et al. Atrial fibrillation begets atrial fibrillation : a study in awake chronically instrumented goats. Circulation, 1995, 92: 1954-1968.
  • 5Ausma J, Wijffels M, Thone F, et al, Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation, 1997, 96: 3157-3163.
  • 6Ausma J, Coumarls WA, Duimel H, et al. Atrial high energy phosphate content and mitochondrial enzyme activity during chronic atrial fibrillation. Cardiovasc Res, 2000, 47 : 788-796.
  • 7Barth AS, Merk S, Amoldi E, et al. Reprogramming of the human atrial transcriptome in permanent atrial fibrillation: expression of a ventricular-like genomic signature. Circ Res, 2005, 96 : 1022-1029.
  • 8Kantor PF, Lucien A, Kozak R, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long- chain 3-ketoacyl coenzyme A thiolase. Circ Res, 2000, 86: 580- 588.
  • 9Leistad E, Borgers M, Christensen G. Atrial contractile dysfunction after short-term atrial fibrillation can be explained by changes in intracellular calcium, but not by atrial ischemia. Circulation, 1996, 94: 1386-1387.
  • 10Leistad E, Aksnes P, Verburg E, et al. Atrial contractile dysfunction after short-term atrial fibrillation is reduced by ver apamil, but increased by BAY-K 8644. Circulation, 1996, 93: 1747-1754.

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