大鼠眶额叶皮质受损破坏新异性探索行为

Lesions to the Orbitofrontal Cortex Produce the Novelty-Seeking Behavior Deficits in Rats

利用旷场测试和Y-迷宫测试两种行为模型检测了双侧眶额叶(orbitofrontal cortex,OFC)电损伤或假损伤雄性SD大鼠的新异性探索行为,探讨了OFC在大鼠探索新异环境中的作用。旷场测试的结果发现,OFC损伤大鼠的行走距离和直立次数较假损组有明显降低;同时,在Y-迷宫测试中与假损伤组大鼠相比,OFC损伤大鼠在新异臂的访问时间和穿梭次数明显降低。提示眶额叶皮质在大鼠新异性探索行为中起着重要作用。

We examined the role of the orbitofrontal cortex （OFC） on exploration of the novel environment using the open-field and Y-maze behavioral paradigms to assess the novelty-seeking behavior of the male Sprague-Dawley rats after receiving bilateral electrolytic lesions of the OFC or sham lesions. In the open-field task, the rats with OFC lesions exhibited reduced average ambulation distance and average rearing number when compared with the animals with sham lesions. Moreover, rats with OFC lesions showed less duration of visits and number of entries in the novel arm in the Y-maze task than the control animals. The current findings suggest that the OFC plays an important role on the novelty-seeking behavior in rats.