肝癌患者外周血LAK细胞活性测定及其影响因素的研究

The Detection and Influence Factors of LAK Cells Activity of the Peripheral Blood from Patients with Hepatocellular Carcinoma

近年来通过白细胞介素2(IL-2)诱导产生的淋巴因子活化性杀伤细胞(Lym-phokine-activated killer cell,LAK)在继承性免疫治疗肿瘤动物模型和人体肿瘤中已显出一定的疗效。

The LAK cells activity of the peripheral blood and it's influenced factors from 33 patients with hepatocellular carcinoma was reported. The results showed that the LAK cells and IL-2 activity were significantly lower in the patients than normal controls (P<0.01) and it was postive correlation between the LAK cells activity and IL-2 activity (P<0.01). In certain extent the LAK cells activity of the patients was increased by increasing IL-2 concentration, but it had not arrived to the normal level. there was an obvious inhibition to LAK cells activity of normal periheral blood cells in the plasma of the patients.