脆性组氨酸三聚体基因及错配修复基因hMLH1、hMSH2在口腔鳞状细胞癌中的表达及意义

Expressions and significance of fragile histidine triad gene and mismatch repair gene hMLH1 and hMSH2 in oral squamous cell carcinomas

目的:探讨脆性组氨酸三聚体基因(FHIT)和错配修复基因hMLH1、hMSH2在口腔鳞状细胞癌组织中的表达及其相互关系。方法:采用免疫组化法检测69例口腔鳞状细胞癌和40例正常口腔黏膜组织中FHIT和hMLH1、hMSH2的表达情况。资料的统计学处理用SPSS软件完成,比较用卡方检验。结果:口腔鳞状细胞癌组织中FHIT、hMLH1和hMSH2的阳性表达率(46.4%,47.8%,55.1%)低于正常口腔黏膜组织(77.5%,77.5%,80.0%),差异有显著性(P<0.05)。结论:FHIT、hMLH1和hMSH2可能在口腔鳞状细胞癌的发生发展中发挥重要作用。

Objective：To study the expressions of fragile histidine triad（FHIT） gene and mismatch repair gene hMLH1 and hMSH2 in oral squamous cell carcinoma（OSCC）.Methods：Immunohistochemical method was used to investigate the expressions of FHIT,hMLH1 and hMSH2 in 69 OSCC and 40 normal oral mucosa.The data was analyzed by Chi-square test.Results：Positive expression rates of FHIT and hMLH1,hMSH2 in OSCC（46.4%,47.8% and 55.1% respectively） were lower than those in normal oral mucosa（77.5%,77.5% and 80.0% respectively）.The differences between OSCC and normal oral mucosa were statistically significant（P〈0.05）,and the correlation between FHIT,hMLH1 and hMSH2 was statistically significant（P〈0.05）.Conclusion：FHIT,hMLH1 and hMSH2 may play an important role in the occurrence and development of OSCC.