小鼠不同脑缺血模型及品系差异

Mouse stroke models and strains-related differences in susceptibility to cerebral ischemia

小鼠脑缺血模型是研究神经细胞死亡、神经功能修复及药物保护作用的实验基础。然而,不同小鼠卒中模型在细胞死亡和神经修复研究中的应用及模仿人类脑卒中事件的能力相差很大;再者,各品系小鼠之间脑缺血敏感性也存在差异。为此,文中对3种小鼠大脑中动脉阻塞模型及小鼠在脑缺血中的品系差异做一综述。

Mouse stroke models provide experiment basis for study of the mechanisms of cell death and neural repair, and the neuroprotective effect of new drugs. There are at least three models of middle cerebral artery occlusion （MCAO） routinely used in experimental study. These models vary widely in their application in study of cell death or neural repair,and simulation of human diseases. This review article is focused on the characteristics of three mouse MCAO models and the strains-related differences in susceptibility to cerebral ischemia.