摘要
研究不同程度认知能力人群的事件相关电位(ERP)的特征,从中提取出能有效识别血管性痴呆(VD)的电生理指标。选择正常青年组、VD组以及与VD同一年龄段的正常老年组作为被试人群,采用视觉通道诱发的oddball实验模式,对ERP信号运用平滑伪魏格纳分布(SPWVD)进行时频分析。通过不同被试人群的群延迟(GD)和瞬时频率(IF)的对比发现,大脑额、中央和顶区ERP信号的群延迟可反映3组不同被试之间认知能力的差异,为VD患者的早期诊断识别提供一个新的途径。
In order to extract electrophysiology characteristic indexes for identifying vascular dementia （VD）, the characters of event related potential （ERP） of persons with different cognitive ability were analyzed. Youth group, vascular demented patient group and healthy elderly control group were chosen as subjects. The visual oddball paradigm was used in the research, and ERP signals were analyzed using smoothing pesudo-Wigner-Ville distribution （SPWVD）. Group delay （GD） and instantaneous frequency （IF） were calculated. The results showed that the GD of ERP from the frontal, central and vertex electrode sites could reflect the difference of cognitive ability of each groups, providing a novel way for early diagnosis of VD.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2009年第5期658-661,667,共5页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金资助(30400101)
关键词
事件相关电位
血管性痴呆
平滑伪魏格纳分布
群延迟
瞬时频率
event-related potential （ERP）
vascular dementia （VD）
smoothing pesudo-Wigner-Ville distribution （SPWVD）
group delay （GD）
instantaneous frequency （IF）
