根除幽门螺杆菌在预防胃癌中的作用

Role of Eradication of Helicobacter pylori in the Prevention of Gastric Cancer

胃癌在全球恶性肿瘤致死亡的原因中位居第二位,幽门螺杆菌(H.pylori)感染是胃癌发生的重要病因。动物研究显示根除H.pylori,特别是在早期阶段,能有效预防胃癌的发生。部分病例通过根除H.pylori可阻止胃癌前病变的发展并可能使其逆转。最新研究表明根除H.pylori可降低胃癌发生的风险,对无萎缩或肠化生者可能尤其有效。本文就根除H.pylori在预防胃癌中作用的研究进展作一综述。

Gastric cancer is the second leading cause of cancer-related death worldwide, Helicobacter pylori （H. pylori） infection is an important risk factor for gastric cancer. Animal studies show that eradication of H. pylori, especially at early stage, is effective in preventing gastric cancer. H. pylori eradication leads to regress the progression of gastric precancerous lesions in a part of cases. The current available data in human studies show that H. pylori eradication can reduce the risk of developing gastric cancer, and this strategy is particularly useful in patients without atrophic gastritis or intestinal metaplasia. This article reviewed the advances in the role of eradication of H. pylori in the prevention of gastric cancer.