摘要
背景与目的:探讨热休克蛋白27(heat shock protein27,HSP27)、三叶因子Ⅱ(trefoil factors2,TFF2)在胃癌和癌前病变组织中的表达及其与幽门螺杆菌(helicobacter pylori,Hp)感染的关系。材料与方法:选取经病理证实的慢性浅表性胃炎、胃溃疡、慢性萎缩性胃炎和胃癌4种不同胃黏膜病变的标本共140例,用免疫组化法检测标本中HSP27和TFF2的表达及幽门螺杆菌的感染情况,分析HSP27和TFF2的表达与幽门螺杆菌感染的关系。结果:除TFF2在胃癌组织中表达降低外,在慢性浅表性胃炎、胃溃疡、慢性萎缩性胃炎和胃癌中,HSP27、TFF2的表达率和Hp的感染率依次呈逐渐增加的趋势。Hp感染组HSP27的表达率高于阴性组,HSP27的阳性表达率与Hp感染率之间呈正相关(r=0.235,P<0.05),Hp感染组TFF2的表达率低于阴性组,TFF2的阳性表达率与Hp感染率之间呈负相关(r=-0.259,P<0.05)。结论:HSP27、TFF2表达和Hp感染与胃癌的发生密切相关,检测这些指标可为胃癌诊断、预后判断和指导治疗提供依据。
BACKGROUND AND AIM：To investigate the expressions of heat shock protein 27（HSP27） and trefoil factors2（TFF2） in gastric cancer and precancerous condition and its correlation with helicobacter pylori（Hp） infection.MATERIALS AND METHODS：The expressions of HSP27 and TFF2 and the infection of Hp were studied by immunohistochemical methods in 140 gastric specimens including 25 chronic superficial gastritis（CSG）,30 gastric ulcer（GU）,35 chronic atrophic gastritis（CAG） and 50 gastric cancers（GC）.RESULTS：In CSG,GU,CAG and GC, the
expression of HSP27 in Hp positive group was significantly higher than that in negative group. The expression of HSP27 was positively correlated with the infection of Hp （r = 0.235, P 〈 0.05）.The expression of TFF2 in Hp positive group was significantly decreased compared with that in negative. The expression of TFF2 was negatively correlated with Hp infection （r = - 0. 259, P 〈 0.05） . CONCLUSION： HSP27, TFF2 and Hp may play important roles in carcinogenesis and progression of gastric carcinoma. The evaluation of HSP27 and TFF2 and tip could provide theoretical basis for diagnosing, evaluating prognosis and guiding treatment of gastric cancer.
出处
《癌变．畸变．突变》
CAS
CSCD
2009年第5期380-383,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
山西省回国留学人员科研资助项目(省留学办〔200609〕)
