葛根素合并丁咯地尔治疗椎-基底动脉供血不足60例临床观察

Clinical observation on puerarin combined buflomedil in the treatment of 60 cases with vertebro basilar artery insufficiency

目的:观察葛根素合并丁咯地尔治疗椎-基底动脉供血不足的临床疗效及经颅多谱勒(TCD)椎-基底动脉血流情况、出凝血时间和凝血酶原时间等。方法:选择椎-基底动脉供血不足患者120例,随机分为治疗组和对照组各60例,对照组单用丁咯地尔治疗,治疗组用葛根素合并丁咯地尔治疗,比较两组的临床疗效、治疗前后椎-基底动脉平均血流速度改善水平及出凝血时间和凝血酶原时间。结果:治疗组总有效率90%,对照组总有效率71.2%,差异有统计学意义(P<0.05)。治疗组椎-基底动脉血流改善情况治疗前后差异有统计学意义(P<0.05),而对照组血流改善情况无差异;出凝血时间和凝血酶原时间两组均无明显差异。结论:葛根素合并丁咯地尔治疗椎-基底动脉供血不足优于单用丁咯地尔治疗,值得推广。

AIM： To observe the clinical efficacy of puerarin combined buflomedil in the treatment of vertebro basilar artery insufficiency and the bleeding and clotting time,the prothrombin time and the average blood flow velocity of vertebral-basilar artery（VBA） by transcranial Doppler（TCD）.METHODS： One hundred and twenty patients with vertebro basilar artery insufficiency were randomized into the treatment group（n=60） which were treated with buflomedil alone and control group（n=60） which were therapied by puerarin combined buflomedil.Changes of the clinical efficacy,the bleeding and clotting time,the prothrombin time and the average blood flow velocity of VBA before and after treatment were observed and compared in the two groups.RESULTS：The total effective rate was 90% in the treatment group and 71.2% in the control group showing statistically significant difference（P〈0.05）.Compared with that before treatment,there was significant difference in improving the blood flow velocity of VBA after treatment in the treatment group（P〈0.05）,while no differences in the control group.There were no significant differences between the two groups in the prothrombin,bleeding and clotting times.CONCLUSION： The therapeutic effect of puerarin combined buflomedil in treating patients with vertebro basilar artery insufficiency is superior to that of buflomedil alone.