盐酸氯胺酮和戊巴比妥钠对树[鼠句]的麻醉效果

Observation of Anesthetic Effect of Katamine and Sodium Pentobarbital on Tree Shrew

目的观察盐酸氯胺酮和戊巴比妥钠对树[鼠句]产生的麻醉效果，以及麻醉产生的副作用，建立安全、可靠的实验树购麻醉技术方法。方法选用成年树[鼠句]共110只，60只腹腔注射盐酸氯胺酮溶液（40mg／kg）；50只腹腔注射戊巴比妥钠（剂量50mg／kg），观察麻醉效果。结果盐酸氯胺酮对树[鼠句]麻醉诱导期为2．78±1．28min，麻醉期为10．12±2．13min，麻醉期间有大量唾液分泌：戊巴比妥钠对树[鼠句]的诱导期为4．84±2．15min，麻醉期为51．95±12．94min，麻醉持续时间长，动物平静，体温下降极显著。结论一定剂量的盐酸氯胺酮和戊巴比妥钠均能对树购产生麻醉效果，并安全可靠；盐酸氯胺酮显效快、麻醉维持时间短，戊巴比妥钠则麻醉维持时间长，动物非常安定。

Objective To observe and compare the anesthetic effect, side effect of ketamine and sodium pentobarbital on tree shrew for establishing the safe, reliable anesthesia methods. Methods One hundred and ten adult tree shrews were divided into two groups： 60 were anesthetized with i.p of ketamine （40 mg/kg）, another 50 with i.p of Sodium pentobarbital （50 mg/kg）. Results In ketamine group, the induction period of anesthesia was 2.78± 1.28 min, maintain duration of anesthesia was 10.12±2.13 min, and the animal with heavy salivation. The induction period of anesthesia by sodium pentobarbital was 4.84±2.15 min, maintain duration was 51.95±12.94 min, all animals keep a stable state but body temperature dropped notable in this group. Conclusion Ketamine and sodium pentobarbital are safe, suitable for tree shrew in these dose. The induction period and maintain of ketamine anesthetic were shorter than those of sodium pentobarbital. More stable anesthesia was obtained by using sodium pentobarbital.