SWI序列在早期原发性帕金森病中的应用价值

The application of SWI sequence in patients with primary Parkinson disease

目的:探讨磁敏感加权成像(SWI)技术在早期原发性帕金森患者黑质形态学及铁质沉积改变的应用。方法:利用3T磁共振成像系统对早期原发性帕金森患者组及正常对照组进行常规序列及SWI序列的扫描。其中帕金森患者(PD)30例,均为早期患者,正常对照组15例。分别在SWI序列上手动测量黑质网状带宽度,黑质致密带宽度,黑质体积,黑质信号值;在T2W上手动测量黑质网状带宽度,黑质致密带宽度。比较分析病例组、正常对照组及病例组健侧与病侧之间的差异。结果:在SWI序列及T2WI上测量PD患者组与正常对照组的黑质体积、黑质致密带宽度、黑质网状带宽度、黑质信号值均无显著性差异(P>0.05)。在SWI序列上测量PD组健侧与患侧黑质体积、黑质致密带宽度、黑质网状带宽度无显著性差异(P>0.05)。PD患者组的黑质信号值明显低于正常对照组(P<0.05)。结论:早期PD患者的黑质形态学较正常对照组无明显差异,但铁质沉积明显高于正常对照组。SWI序列对于诊断早期帕金森病是一种及其敏感的新型检查方法。

Objective： Evaluating the ability of SWI（snsceptibility weighted image） sequence to detect the changes of morphology and iron deposition in the early stage of primary Parkinson disease（PD）. Methods：Thirty early stage PD patients and fifteen normal controls had been scanned with routine sequences and SWI sequences by 3T MR. The width of the SNe, SNr and the volume and signal density of the substanfia nigra on SWI images were meamured. And the width of the SNr and SNe were also mearsured on T2W images. The data of measured were analyzed and compared. Results：The width of the SNe, SNr and the volume of the substantia nigra have no significant re- duce in PD group compared with the normal control group in beth SWI and T2W images （ P 〉 0.05）. And also in SWI the width of the SNc, SNr and the volume of tlm cubstanfia nigra have no significant reduce in PD group between the health side and the sick side. The signal density of substanfia nigra was signitieanfly diminished in PD group compared with the normal control group in SWI image （ P 〈 0.05）. Conclusion： Morphology of substantia nigra in early stage of the PD patients have no significant changes compared with normal controls. SWI sequence could be a new and sensitivity method for dignosis of PD in the early stage.