ω-3鱼油脂肪乳剂对胃肠道术后病人炎症反应和凝血功能的影响

Influence of ω-3 fish oil lipid emulsion on inflammatory response and coagulation function in postoperative patients with gastrointestinal disease

目的:研究ω-3鱼油脂肪乳对胃肠道手术后病人炎症反应和凝血功能的影响。方法:胃肠道手术病人30例,随机分为鱼油(FO)组和中长链脂肪乳(MCT)组,术后PN支持方案MCT组给予中长链脂肪乳剂,FO组加用ω-3鱼油脂肪乳剂,其他治疗措施相同。检测所有病人治疗前后外周血中炎症反应指标和凝血功能指标。结果:FO组病人术后炎症反应指标水平显著低于术前(P<0.05),MCT组病人该指标则无显著差异甚至术后略有升高;凝血功能指标两组病人手术前后均无显著性差异(P>0.05)。结论:ω-3鱼油脂肪乳剂能减轻胃肠道手术后病人的炎症反应,对凝血功能无明显影响。

Objective： To study the influence of ω-3 fish oil lipid emulsion on inflammatory response and coagulation function in postoperative patients with gastrointestinal disease. Methods： 30 patients with gastrointestinal disease were divided into fish oil group（FO） and MCT group（MCT）. The MCT pa- tients received M/L lipid emulsion, and those in FO received ω-3 fish oil additionally. Inflammatory re- sponse and coagulation function were detected before and after operation. Results ： The level of inflam- matory response in FO group decreased significantly after operation and it didnt in MCT group. There was no difference in coagulation function between the two groups. Conclusion： ω-3 fish oil lipid emulsion can release the inflammatory response after operation in patients with gastrointestinal disease, and there were no influence on the coagulation function.