低剂量螺旋CT联合血清p16基因甲基化检测筛查早期肺癌的研究

Low-dose computed tomography and serum p16 gene methylation measurement for screening of early lung cancer

目的:研究胸部低剂量螺旋CT联合血清p16基因甲基化检测筛查早期肺癌的可行性。方法:本院体检的无症状肺癌高危人群共2332例按2:1随机分为2组,低剂量螺旋CT-p16组1555例,首先给予低剂量螺旋CT扫描,发现肺非钙化结节者行常规剂量CT及血清p16基因甲基化检测;标准剂量CT-p16组777例,给予标准剂量CT扫描,发现肺非钙化结节者行血清p16基因甲基化检测。结果:低剂量螺旋CT-p16组中11.4%及标准剂量CT-p16组12.1%患者可疑肺癌,其中低剂量螺旋CT-p16组中108例及标准剂量CT-p16组中50例确诊为肺癌。2组肺癌检出率比较差异无统计学意义(P>0.05)。结论:低剂量CT联合血清p16基因甲基化检测是一种敏感、安全、可行的筛查早期肺癌的方法。

Objective To study the feasibility of detecting lung cancer in asymptomatic individuals at high risk for lung cancer by low-dose computed tomography combined with detection of p16 gene methylation in serum.Methods A total of 2332 subjects were randomly divided into two,LDCT-p16 group（1555 cases）and SDCT-p16 group（777 cases）.LDCT-p16 group was performed screening by low-dose computed tomography scan firstly.If the images showed noncalcified pulmonary nodule,standard-dose spiral computed tomography and the serum p16 gene methylation detection were performed.SDCT-p16 group was performed screening by standard-dose computed tomography.If the images showed noncalcified pulmonary nodule,serum p16 gene methylation detection was performed.Results A total of 11.4 % of LDCT-p16 group and 12.1% of SDCT-p16 group were found suspective lung cancer.In LDCT-p16 group and SDCT-p16 group,108 and 50 patients were diagnosed lung cancer,respectively.There was no statistic difference between two groups（P0.05）.Conclusion The low-dose computed tomography combined with detection of p16 genemethylation in serum is sensitive,safe and feasible for screening in lung cancer.