性激素对雄性小白鼠学习记忆和脑中GABA_A受体亲和力的影响

EFFECTS OF SEX STEROIDS ON LEARNING AND MEMORY AND AFFINITY OF GABA A RECEPTOR IN CEREBRAL CORTEX AND HIPPOCAMPUS OF MALE MICE

本文研究了丙酸睾丸酮（Ｔ）、黄体酮（Ｐ）和苯甲酸雌二醇（Ｅ２）对雄性小白鼠学习记忆及皮层、海马中ＧＡＢＡＡ受体亲和力的影响。结果表明，Ｔ降低皮层、海马中ＧＡＢＡＡ受体亲和力，但不影响学习记忆能力。Ｐ对两者ＧＡＢＡＡ受体亲和力无影响，Ｅ２降低了皮层ＧＡＢＡＡ受体亲和力而不影响海马ＧＡＢＡＡ受体亲和力。Ｐ和Ｅ２可损害学习记忆能力。这为性激素对学习记忆功能的药理学效应及其在脑中的作用机制提供了一些有价值的参考资料。

The paper studied the effects of testosterone(T), progesterone(P) and estradiol(E2) on memory and GABAA receptor affinity in cerebral cortex and hippocampus of male mice by using AMG-2 type Y maze and radio-receptor binding assay. The results showed that intramuscular injection (im) of T did not change response number (RN) and error number (EN) during learning and review, but decreased the affinity of GABAA receptors (P<0001 or P<005). P im increased RN and EN in learning, but did not change the affinity of GABAA receptor, E2 im increased RN and EN (P<001) in learning and RN(P<005) and EN(P<005) in review. It decreased the affinity of GABAA receptors in cerebral cortex, but not that of hippocampus. These results suggested that the impairment of P and E 2 on memory have no relation to the affinity of GABAA receptors for GABA.