维生素D受体基因多态性与结核易感性关系的荟萃分析

Meta-analysis of relationship of vitamin D receptor gene polymorphism and tuberculosis susceptibility

目的应用荟萃分析探讨维生素D受体（VDR）基因FokI、TaqI多态性与结核易感性的关系。方法在中国知网（CNKI）、中国生物医学文献数据库（CBM）、万方数据资源系统、MEDLINE和PubMed中，应用关键词“结核”、“基因多态性”或“遗传多态性”、“等位基因”、“VDR”、“tuberculosis”或“alleles”搜索1980年1月至2007年11月发表的相关中英文文献，最终人选文献14篇。应用RevMan4．2软件包分别对14项研究结果进行数据分析。结果荟萃分析计算得出合并OR值（95％CI）：Ff／FF基因型为1．12（0．98～1．28），ff／FF基因型为1．66（1．12～2．46），Tt/TT基因型为0．97（0．82～1．14），tt/TT基因型为1．27（0．96～1．69）。计算Fokl基因的失安全系数为109．69，TaqI基因的失安全系数为75．24，说明分析结果可靠。结论维生素D受体基因FokI多态性与结核易感性有关，TaqI多态性与结核易感性尚无明确关系。

Objectives To provide a quantitative summary in estimating the association between polymorphisms of 2 loci of FokI and TaqI in vitamin D receptgr gene and susceptibility to tuberculosis by means of meta-analysis. Methods Databases CNKI, CBM, WanFang DATA, MEDLINE and PubMed were searched using ＇＂ VDR＂, ＂polymorphisms＂ or ＂alleles＂, in combination with ＂tuberculosis＂, and a manual search of citations from relevant original studies and literature between January 1980 and November 2007 was also performed. RevMan 4.2 was applied in the process of analyzing the data of 14 case-control studies. Results The summary ORs for studies with polymorphisms of FokI, TaqI loci of the VDR gene were 1.12 （95%CI： 0.98-1.28） in Ff vs FF, 1.66 （95%CI： 1.12 -2.46） in firs FF, 0.97 （95%CI： 0.82 - 1.14） in Tt vs TT, 1.27 （95% CI： 0. 96 - 1.69） in tt vs TF. The fail-safe number was 109. 69 for FokI and 75.24 for TaqI. The analysis result was reliable. Conclusions Polymorphisms at FokI loci （VDR-ff） showed statistically significant association between the VDR variants and susceptibility to tuberculosis, and variant in the TaqI locus failed to show statistically significant association.