安徽省莱姆病血清流行病学研究

Investigation on the Seroepidemiology of Lyme Disease in Anhui Province

目的：对莱姆病进行血清流行病学研究。方法：间接免疫荧光试验（ＩＦＡ）和酶联免疫吸附试验（ＥＬＩＳＡ）。结果：检测４５９份自然人群血清、１２４份临床病人血清和４３８份牛、羊、狗、鼠等动物血清标本，抗莱姆病螺旋体抗体（ＩｇＧ）阳性率，自然人群中平原和山区分别是１１７％、４４３％（χ２＝４７３，Ｐ＜００５）；不同类型临床病人中以皮肤损害和关节炎患者的阳性率最高，分别是１８１８％和１４７１％；动物血清中，平原和山区牛的阳性率分别为１８１８％和３２６１％（χ２＝４０２，Ｐ＜００５），羊的阳性率分别为２２２２％和６１２８％（χ２＝２９２７，Ｐ＜００１），狗和鼠阳性率分别为３０％和３５７％。结论：不同地理景观中动物血清阳性率的高低与人群血清学结果相一致，莱姆病疫区主要在山区。

Antibody (IgG) against Borrelia burgdorferi strain B31 were tested among 459 sera specimen of natural population, 124 sera of patient and 438 sera of animals (cattle, goat, dog and mice) by indirect immunofluorescent assay technique (IFAT) and ELISA. Specimen were collected from 5 counties of mountain and plane areas in Anhui province from November 1996 to June 1997. The positive rate were 1.17% for plane area and 4.43% for mountains (χ2=473,P<005) in natural population, 1818% for skin illness and 1471% for arthritis in patient; The positive rate (cattle) was 1818% for plane area and 3261% for mountains(χ2=402,P<005). The goat was 2222% for plane area and 6128% for mountain (χ2=29.27,P<0.01); The dog and mice were 30%, 3.57% respectively.The results showed that the detection of animal sera (L.D-Ab) conform with human being, Mountain areas were the main endemic of Lyme Disease in Anhui. The goat is possible host animal in endemic.