济南东郊秋冬型恙虫病流行病学研究

Studies on the Epidemiology of Tsutsugamushi Disease of the AutumnWinterType in the Eastern Suburbs of Jinan

目的：由于济南东郊历城区１９８８年１０月首次发现恙虫病临床病例而开展流行病学调查。方法：采用斑点酶标染色法（ＩＥＡ），检测患者、鼠类血清抗恙虫病立克次体（Ｒ．ｔ）；采用间接免疫荧光法（ＩＦＡ），进行血清分型；同时进行病原分离。结果：有７个乡镇发生恙虫病流行，属秋冬型；流行季节储存宿主和传播媒介以黑线姬鼠和小盾纤恙螨为主；秋冬型恙虫病立克次体属弱毒株，接种小白鼠后无规律性死亡；从３组鼠类标本接种小白鼠的组织印片分离出Ｒ．ｔ，血清抗Ｒ．ｔ阳性。结论：血清学分型属Ｇｉｌｉａｍ型；

This paper reported that cases of tsutsugamushi disease was firstly found in the eastern suburbs of Jinan in October 1988,and has spread to 7 village communities ever since.The results showed that epidemical characterization differed greatly from those in southern regions.The major findings were as follows:Prevalence of tsutsugamushi disease belonged to the autumnwinter type;The main reservoir of infection were Apodemus agrarius;The transmitting vector was Leptotrombidium (L) scutellare;The pathogen of tsutsugamushi disease of the autumnwinter type belonged to lowvirulent strain,and inoculated mice could not regularly die from the infection;Rickettsia tsutsugamushi could be detected on tissular smears in 3 groups of mice inoculated with suspension of internal organs of mice,and specific antibodies could be detected in the sera;Serological typing of their sera showed that they belonged to the Gilliam type;Natural foci in Jinan could be divided into hilly land type.