融合蛋白与病毒入膜机制研究进展

Research Advances on Fusion Peptide and Mechanisms about Virus Penetration into Membrane

包膜病毒感染细胞的第一步即病毒与靶细胞膜的融合，它由病毒包膜上的融合蛋白诱发。融合蛋白与受体分子相互作用后暴露出融合肽，它伸向靶膜使两膜紧密接近后，多肽周围的脂质分子进一步重排，通过中间态最后发生融合。

The first step of viral infection is virus fusion with target membrane.The process is induced by fusion peptide located in glycoprotein on virus membrane.Fusion peptide exploited after interaction with receptors and penetrates into target cells membrane. Lipid molecules surrounding peptides are rearranged and membrane fusion occurs through the formation of a intermediate state.This review introduces the research advances of viral fusion peptides and its mechanism of penetrating into membrane.